Modification of Morphine Dependence under Chronic Pain and Its Mechanism
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چکیده
منابع مشابه
Comparative Effect of Cinnamon Essential Oil, Diclofenac and Morphine on Acute and Chronic Pain in Mice
Backgrounds and Aims: Cinnamomum Zeylanicum is a medicinal herb used in Iranian traditional medicine as an analgesic spice, which its analgesic effect has been experimentally confirmed. Thus, this study was conducted to compare the antinociceptive effect of cinnamon essential oil (CEO) with those of Morphine and Diclofenac in mice. Materials and Methods: 80 male albino mice were selected and...
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15 صفحه اولAttenuation of morphine tolerance and dependence by thymoquinone in mice
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متن کاملChronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity.
Tolerance to the analgesic effects of an opioid occurs after its chronic administration, a pharmacological phenomenon that has been associated with the development of abnormal pain sensitivity such as hyperalgesia. In the present study, we examined the role of spinal glutamate transporters (GTs) in the development of both morphine tolerance and associated thermal hyperalgesia. Chronic morphine ...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2001
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.121.909